Eine Therapie mit immunmodulatorischen Medikamenten ging mit höheren CYR61-Konzentrationen einher. Patienten in "complete response" oder "very good partial response" hatten signifikant höhere CYR61-Werte. Hohe CYR61-Konzentrationen in der Myelom-Gruppe waren assoziiert mit günstigen Prognosefaktoren wie einem Hämoglobin-Wert > 10 g/dl, einem normwertigen Serum-Albumin, einer niedrigen Laktatdehydrogenase, einer geringen Konzentration von Immunglobulinen im Serum und einer normwertigen free light chain ratio. Es zeigten sich signifikant höhere CYR61-Werte in der Gruppe der Myelom-Patienten im Vergleich zur Gruppe der Osteoporose-Patienten. In der vorliegenden Dissertation, wurde die CYR61-Konzentration im peripheren Blut bei Myelom-, Osteoporose-Patienten und gesunden Probanden gemessen. Im Zusammenhang mit dem Multiplen Myelom konnte in Studien gezeigt werden, dass CYR61 dort in signifikant höheren Konzentrationen vorliegt und hohe CYR61-Werte bei Myelom-Patienten mit einer besseren Prognose und einem längeren Überleben einherzugehen scheinen. Im Knochen ist CYR61 zuständig für die Angiogenese, die Proliferation und Migration mesenchymaler Stammzellen sowie für die Differenzierung von Osteoblasten und Endothelzellen. Das Cystein-rich-Protein 61 (CYR61) ist ein Signalprotein, das bei verschiedensten Prozessen im menschlichen Körper eine Rolle spielt. In den letzten Jahrzehnten haben sich mehrere klinische, laborchemische sowie genetische Parameter als Risikofaktoren etabliert. Cancer 2010.īeim Multiplen Myelom handelt es sich um eine klinisch sehr heterogene Erkrankung, bei der eine genaue Prognoseabschätzung schwierig ist. The current results indicated that 1) serum B2M is an independent predictor of asymptomatic MM progression, and 2) serum B2M adds prognostic information when combined with the most widely used prognosticators of asymptomatic MM progression. The model that included serum B2M along with sMC, uMC, and BMPC was able to predict disease progression better than the model that was based on sMC, uMC, and BMPC without serum B2M (C statistics, 0.760 vs 0.726). Serum B2M was combined with sMC, uMC, and BMPC to create a risk-stratification model based on 4 groups with different risk of progression: very low (5-year risk, 0%), low-intermediate (5-year risk, 19.6%), high-intermediate (5-year risk, 60.7%), and high (5-year risk, 80.7%). In multivariate analysis, serum B2M was selected as an independent predictor of progression (hazard ratio, 3.30 P =. 001), and bone marrow plasma cells (BMPCs) (P <. 001), urinary monoclonal component (uMC) (P <. 001) along with serum monoclonal component (sMC) (P <. In univariate analysis, a serum B2M level >2.5 mg/L was associated with an increased probability of disease progression (5-year risk, 64.5% P <. This study was bases on a consecutive series of 148 patients with asymptomatic MM and explored the cumulative probability of progression to symptomatic MM as the primary endpoint. If you have any questions feel free to post.Although serum beta-2 microglobulin (B2M) represents a key variable for symptomatic multiple myeloma (MM) prognostication, its role in predicting the risk of progression of asymptomatic MM to symptomatic disease has not been explored. Version 1.8 is on its way and someone has made a mod named, Super Mario War Net Play, though it is for download but it is a little buggy. So far I probally have came up with 100 maps and I still have a lot more in my head so as time goes by I will post them for download. I do not think version 1.7 comes with a map maker though but if enough people show interest I will put up the 1.6 map maker download that I have. It is fun being Sonic while stomping on Peach's head. (The source code is also avaliable) What the best part is that you can edit the graphics to what ever you want and you can also create your own maps. If you do not have a PSP you can also play it for many other systems such as a Nintendo DS, PC, Mac, and more. It's a tribute to Nintendo and the game Mario War by Samuele Poletto. The goal is to stomp as many other Marios as possible to win the game. Super Mario War is a Super Mario multiplayer game. You can download your copy of it here while I talk about it. I use to play it back in 2004 but then for no reason I stopped until a couple of weeks ago I found out that the creators of the game made it for the PSP also. Lately I have been playing the game, Super Mario War, a lot.
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